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Document Type : Latin Dissertation
Language of Document : English
Record Number : 150520
Doc. No : ET22312
Main Entry : Clayton Young
Title Proper : Initiation of Apoptosis by Application of High Intensity Electric Fields
Note : This document is digital این مدرک بصورت الکترونیکی می باشد
Abstract : Exposure of suspended cells to high-intensity, pulsed electric fields ofnanosecond-scale duration force a significant percentage of the treated cell populationto undergo apoptosis, or genetically mediated cell death. Field-treated samples show anincrease in the population fraction demonstrating morphological changes to the cellstructure which are indicative of the apoptotic cascade. Flow cytometric inspection alsorevealed negligible plasma membrane permeability, implying that field-induced changeswere localized within the intracellular space. Changes to the cell ultrastructure initiatedsolely by the electric field stimulus demonstrate the ability to manipulate intracellularprocesses noninvasively without the need of exogenous molecules or organisms. Theapoptotic response to externally applied electric fields demonstrate a possible method ofdeleting undesired cell populations noninvasively without evoking undesired side-effectscompared to more traditional chemotherapeutic, radiotheraputic, or surgical techniques.-...,..tested for theQ1 PC1 bus cardBoth these projects mere sofixare des elopment efforts tonards contributing to dlfferentaspects of Roboucs and lZ1echatronics projects m the Controls and Roboucs Group..
Subject : Electericl tess
: برق
electronic file name : TL45518.pdf
Title and statement of responsibility and : Initiation of Apoptosis by Application of High Intensity Electric Fields [Thesis]
 
 
 
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