A Dual Acousto-Optic Laser Scanning Microscope System for the Study of Dendritic Integration: Design, Construction, and Preliminary Results

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" A Dual Acousto-Optic Laser Scanning Microscope System for the Study of Dendritic Integration: Design, Construction, and Preliminary Results "

Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	151828
Doc. No	:	ET23620
Main Entry	:	Vijay Iyer
Title Proper	:	A Dual Acousto-Optic Laser Scanning Microscope System for the Study of Dendritic Integration: Design, Construction, and Preliminary Results
Note	:	This document is digital این مدرک بصورت الکترونیکی می باشد
Abstract	:	Recent research has highlighted the vital role played by dendrites ineffecting the computational properties of single neurons in the central nervoussystem (CNS). An ultraviolet (UV) acousto-optic laser scanning microscopesystem was developed that enables UV laser pulses to be delivered to multipleuser-selected sites in the microscope's specimen plane with high spatial ( 4 Opm)and temporal (e20ps) resolution. By employing "caged" neurotransmitters, thesystem can effect physiologically realistic spatio-temporal patterns of "synaptic"stimulation to the dendrites of a single cultured neuron. This system wascombined with a previously developed acousto-optic laser scanning system forfast, multi-site optical recording of electrical activity (Bullen et al. 1999). Thiscombination-the "Dual Scanner"-allows the study of important dendriticquestions such as the underlying mechanisms of spatial and temporalsummation. This thesis describes several current outstanding questions ofdendritic integration, the design and construction of the system, and somepromising preliminary results.........-....,....-...,..tested for theQ1 PC1 bus cardBoth these projects mere sofixare des elopment efforts tonards contributing to dlfferentaspects of Roboucs and lZ1echatronics projects m the Controls and Roboucs Group..
Subject	:	Electericl tess
	:	برق
electronic file name	:	TL46864.pdf
Title and statement of responsibility and	:	A Dual Acousto-Optic Laser Scanning Microscope System for the Study of Dendritic Integration: Design, Construction, and Preliminary Results [Thesis]