A Mathematical Model of the Mammalian Ventricular Cell: Mechanistic Explanations of Long Q-T Syndrome

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" A Mathematical Model of the Mammalian Ventricular Cell: Mechanistic Explanations of Long Q-T Syndrome "

Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	151312
Doc. No	:	ET23104
Main Entry	:	Kimberly Nichole Daniel
Title Proper	:	A Mathematical Model of the Mammalian Ventricular Cell: Mechanistic Explanations of Long Q-T Syndrome
Note	:	This document is digital این مدرک بصورت الکترونیکی می باشد
Abstract	:	We have developed a mathematical model of a rabbit ventricular cell based onavailable whole cell voltage clamp data. The model consists of three components: aHodgkin-Huxley type membrane model describing the electrical activity of the cellmembrane; and intracellular fluid compartment model; and a small extracellular cleftspace. Material balances for Na+, k, and caZ* provide the describing equations for theintra and extracellular spaces. A model for the sarcoplasmic reticulum is also provided inthe intracellular fluid compartment model. Whole cell voltage clamp data from the rabbitventricular myocyte was utilized to characterize the kinetics of the ionic membrane.-....,....-...,..tested for theQ1 PC1 bus cardBoth these projects mere sofixare des elopment efforts tonards contributing to dlfferentaspects of Roboucs and lZ1echatronics projects m the Controls and Roboucs Group..
Subject	:	Electericl tess
	:	برق
electronic file name	:	TL46338.pdf
Title and statement of responsibility and	:	A Mathematical Model of the Mammalian Ventricular Cell: Mechanistic Explanations of Long Q-T Syndrome [Thesis]